News & Publications

Closing the Social Care Referral Loop: What Oncology Clinics Screen For But Can’t Track

About XanthosHealth. XanthosHealth built ConnectedNest, a patient-led, oncology-focused platform that connects patients with cancer to community-based services with a committed response-time and real-time status visibility. Founded by University of Minnesota professors Pinar Karaca-Mandic, PhD and David Haynes, PhD, the company is supported by multiple NIH grants and collaborates with oncology clinics, health systems, and community …

About XanthosHealth. XanthosHealth built ConnectedNest, a patient-led, oncology-focused platform that connects patients with cancer to community-based services with a committed response-time and real-time status visibility. Founded by University of Minnesota professors Pinar Karaca-Mandic, PhD and David Haynes, PhD, the company is supported by multiple NIH grants and collaborates with oncology clinics, health systems, and community based organizations.

The operational gap after screening

Most oncology clinics screen for health-related social needs such as transportation, food, housing, finances, and caregiver strain. Unfortunately, positive screens often disappear into voicemail or community based organization services may no longer exist; capacity and eligibility are opaque; and clinical teams rarely see definitive confirmation that the patient received the needed information. Social workers are often overwhelmed with a larger than 300:1 patient:social worker ratio so with limited time and often outdated directories, they struggle to get patients connected with the care and services they need.  Additionally, current systems lack the closed-loop data which tells them if the patient received the services.

The downstream risk impacts clinical outcomes: avoidable missed medical appointments, missed infusions and radiation sessions, disease progression, avoidable hospitalizations or ED visits, and reduced survival rates.

What ConnectedNest changes

ConnectedNest is not another directory. It is not another googling of organizations one by one, calling them, asking for eligibility, capacity, and applying for various services and programs. It’s a platform that makes acknowledgment, scheduling, and completion of non medical services seamless, and visible to patients, community-based organizations (CBOs), and oncology teams. It is the one of its kind promise to surround the patient with excellence in community support for non-medical needs so that the patient, their care givers and clinical teams can focus on the medical care and treatments.

  • EmpowerNest lets patients and caregivers complete a brief self-screen and immediately see a curated, local list that matches their eligibility and language. With consent, they request connections now or at home—without starting over later.
  • CommunityNest gives CBOs a single queue to accept and manage referrals and do secondary referrals to other relevant CBOs for patients. CBO partners update eligibility and capacity/waitlist, commit to a response target of ≤48 hours, and update status in real time.
  • EngageNest provides navigators and oncology teams a consolidated view of referral status—acknowledged, scheduled, completed, or re-routed—so follow-up is exception-based rather than blanket chase work.
Closed-loop oncology referral process showing acknowledged, scheduled, and completed stages

What day zero looks like

At the first oncology visit or the social worker follow-up, the patient completes the self-screen in EmpowerNest with the social worker at their side. Alternatively, patients may just do their self-screening of non-medical needs on their own, at their own time, at their own place, at their own pace, without any discomfort to share information with a clinical staff member. The platform presents a ranked list—transportation, nutrition support, financial counseling—mapped to what matters most now. Because only available programs are presented. The patient can confidently initiate the connection and trust that the CBO will acknowledge within the target window of 48 hours or less. Between visits, the patient can revisit the list, change priorities, and request additional support without having to reach out to the social worker or retelling their story to a CBO.

The result is a shorter initial consult, fewer manual follow-ups, and a shared source of truth about whether non-medical barriers were addressed.

Governance and privacy posture

ConnectedNest is built for HIPAA-aligned operations. Patients initiate sharing and can see what will be shared before they consent. Access is limited by role so social workers, clinical staff, and CBO personnel view only the information required to fulfill the referral. Every status change is timestamped and attributable, creating an auditable trail that supports both operational reviews and value-based reporting.

Deployment without an IT project

Programs can launch quickly using a secure, browser-based workflow and light training. This EHR-agnostic platform enables rapid deployment and allows teams to prove the operational model without immediate integration requirements. When integration becomes necessary, the system connects via standards-based FHIR APIs using the SMART on FHIR framework. In short: start now; add EHR connections that support the social worker’s process flows that are unique to each system. 

What to measure

A closed-loop pathway improves only when it’s measured with clear operational metrics. ConnectedNest supports a common set of definitions so performance can be compared across sites and partners:

  • Acknowledgment time: patient request to CBO acknowledgment
  • Time-to-service: acknowledgment to first encounter
  • Completion rate: proportion of referrals resulting in service delivery
  • Secondary referrals: Additional services provided to patients through a secondary CBO referral.
  • Social Worker Efficiency: change in follow-up volume and phone time per patient

These measures don’t replace clinical outcomes, they protect them by reducing non-medical causes of delay.

Early signals from the field

In pilot work, patients selected organizations mapped to their immediate needs and were able to initiate connections without staff finishing the referral for them. CBO partners acknowledged within the ≤48-hour target window, and social workers reported fewer follow-ups because capacity and status were visible. Most importantly, patients did not experience delays attributable to waitlists or unanswered messages.

Why this scales in oncology

ConnectedNest curates participating CBO partners, sets expectations for response and status updates, provides only available programs to patients, so dead ends are avoided, and tracks the same KPIs across markets. The platform can be used independent of an EHR integration so getting started requires no IT resources.  Meanwhile the platform can, when the clinic or health system desires, integrate with EHRs using a  SMART on FHIR connection.

What this means for providers

For oncology leadership, the value proposition is significantly improving the social worker’s efficiency and ability to support patients without additional headcount. Providers and Social Workers can see that the patient has connected with non medical services and when they are completed. Community partners work from one queue with clear expectations rather than fragmented emails. And executives get clear metrics—acknowledgment time, time-to-service, completion, and re-route efficiency.


Continue the conversation

  • Explore ConnectedNest → /connectednest
  • Publications & grants → /publications
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ConnectedNest in oncology: a shared workflow for accountable social care

Cancer care is time-sensitive. Yet many of the delays cancer survivors face aren’t clinical at all—they’re the ripple effects of transportation trouble, food insecurity, unstable housing, lost wages, or caregiver strain. Most health systems ask about these needs but far fewer can consistently turn a positive social needs screen into a referral that translates into …

Cancer care is time-sensitive. Yet many of the delays cancer survivors face aren’t clinical at all—they’re the ripple effects of transportation trouble, food insecurity, unstable housing, lost wages, or caregiver strain. Most health systems ask about these needs but far fewer can consistently turn a positive social needs screen into a referral that translates into the survivor receiving services from a community-based organization (CBO). This is where real-time connection—not another directory—moves the needle.

Patients Shouldn’t Have to Chase Help: Closing the Referral Loop

When a referral disappears into voicemail or an inbox, everyone feels it. Patients wait without knowing if anyone will reach out. Navigators burn time chasing updates and worrying whether patients are getting the non-medical but critically important services they need. Clinicians worry that a missed infusion or medical appointment will compromise patients outcomes and their own income. This is how well-intentioned directories fall short: they publish names and numbers BUT

  • DON’T commit to a timely response
  • DON’T guarantee service delivery for eligible patients
  • DON’T close the feedback loop with healthcare teams. 

All too often, referred patients – who are already overwhelmed – give up hope that there are services available to address their social need. Medical teams don’t know that patients have been left hanging, and even if they do, clinic staff don’t have easily accessible information – or time – to re-direct patients to other programs.  

Smiling woman in headscarf at home accepts a glass of water from a clinician in scrubs holding a tablet during a supportive care visit.

What accountability looks like in practice

ConnectedNest approaches the problem from three vantage points—patients, community partners (CBOs), and oncology teams—so each can do their part without extra friction. 

  • EmpowerNest empowers patients to self-identify their needs and choose a local CBO. Patients have choice and consent-based sharing.
  • CommunityNest creates one queue for Community-Based Organizations. CBOs commit to a  ≤48-hour response time and transparency regarding eligibility criteria, capacity and waitlist. 
  • EngageNest offers care teams one platform for efficient monitoring of patients’ needs and referral status. This helps assure that non-medical but critical social support services are addressed during  patients’ medical treatment planning. 

Early signals from the field

In a recent study, patients successfully selected organizations when choices were mapped to their personal and immediate needs. They were able to choose a local partner themselves, without staff assistance. CBO partners routinely acknowledged referrals within the target window of 48 hours. Clinical navigators reported more workflow efficiency with fewer phone calls. The platform made it easy to identify patients needing to be referred to different providers. The most important outcome: patients didn’t experience delays in getting services. 

Why this scales in oncology

Curated partners have a meaningful relationship with Xanthos and feel actively engaged as part of their patients’ care team. This dynamic leads to their willingness to initiate secondary referrals to network CBOs when new or additional patient needs are identified. The platform makes it easy for CBOs to engage another vetted program with the same KPIs and performance accountability – thus maintaining patients’ trust. 

A path from pilot to portfolio

Identifying and addressing non-medical or social care needs is critical to the efficacy of a patient’s cancer care plan. ConnectedNest sets a standard for its network of Community-Based Organizations and reports outcomes. When a patient’s need is acknowledged quickly, support services are available and accessible, and status is visible to oncology care teams, a referral becomes part of the treatment plan—not a hope.

Explore ConnectedNest → /connectednest
Publications & grants → /publications
Talk with the team → /contact

Home » News & Publications

Enhancing cancer care through digital social care referrals: insights from the ConnectedNest pilot study

Over 8 million patients experiencing cancer face health-related social needs (HRSN) challenges, such as food, housing, and financial insecurity, that directly impact their health outcomes. While patients may participate in the screening of unmet social needs with their healthcare provider, it is not well understood if patients will self-screen and act on referrals to community …

Over 8 million patients experiencing cancer face health-related social needs (HRSN) challenges, such as food, housing, and financial insecurity, that directly impact their health outcomes. While patients may participate in the screening of unmet social needs with their healthcare provider, it is not well understood if patients will self-screen and act on referrals to community services. Therefore, we conducted a mixed-methods study in which we pilot-tested a patient-centered oncology-focused digital social care referral platform, ConnectedNest.

Haynes, D., Trempe, E., Iwan, A., Osegueda, E., Sarkin C., Cross, D., Begnaud, A., Newcomer, K., Parson, H., Karaca Mandic, P., Enhancing cancer care through digital social care referrals: insights from the ConnectedNest pilot studySupportive Care in Cancer, June 5, 2025

 “ConnectedNest: a digital platform connecting individuals with cancer to social care”, National Institutes of Health, National Cancer Institute, Prime Awardee: XanthosHealth, $1,880,487, 09/20/2024-08/31/2026 ( PI of grant: David Haynes).

A Human-Centered Approach for Designing a Social Care Referral Platform

Our results summarize several key findings useful for patients, clinical teams, and staff of CBOs when designing a social care referral platform. Our user testing highlighted that patient-facing interfaces offer tremendous opportunities to allow patients to be the leader of the social care referral process. CBOs have varying needs that must be addressed, and providing …

Our results summarize several key findings useful for patients, clinical teams, and staff of CBOs when designing a social care referral platform. Our user testing highlighted that patient-facing interfaces offer tremendous opportunities to allow patients to be the leader of the social care referral process. CBOs have varying needs that must be addressed, and providing CBO staff with opportunities to connect with patients is critical. Finally, health care teams have more structured workflows. Integration within the electronic health record system provides opportunities for health care staff to support their patients more easily given these barriers.

Haynes D, Cheng P, Weaver M, Parsons H, Karaca-Mandic P “A human-centered approach for social care referrals facilitated through a health information technology platform”, Applied Clinical Informatics, October 2024

Addressing social needs in oncology practices: A case study of a patient-centered approach using health information technology

Given the dramatic growth in the financial burden of cancer care over the past decades,individuals with cancer are increasingly susceptible to developing social needs (e.g., housing instability and food insecurity) and experiencing an adverse impact of these needs on care management and health outcomes. However, resources required to connect individuals with needed social and community …

Given the dramatic growth in the financial burden of cancer care over the past decades,
individuals with cancer are increasingly susceptible to developing social needs (e.g., housing instability and food insecurity) and experiencing an adverse impact of these needs on care management and health outcomes.

However, resources required to connect individuals with needed social and community services typically exceed the available staffing within clinical teams. Using input from focus groups, key informant interviews, user experience/user interface testing, and a multidisciplinary community advisory board, we developed a new technology solution, ConnectedNest, which connects individuals in need to community based organizations (CBOs) that provide services through direct and/or oncology team referrals, with interfaces to support all three groups (patients, CBOs, and oncology care teams).

After prototype development, we conducted usability testing, with participants noting the importance of the technology for filling a current gap in screening and connecting individuals with cancer with needed social and community services. We employ a patient-empowered approach that engages the support of an individual’s healthcare team and community organizations.

Future work will examine the integration and implementation of ConnectedNest for oncology patients, oncology care teams, and cancer-focused CBOs to build capacity for effectively addressing distress in this population.

Parsons H, Haynes D, Blaes A, Church T, Halberg J, Johnson S, Karaca-Mandic P “Addressing Social Needs in Oncology Practices: A Case Study of a Patient-Centered Approach using Health Information Technology”, Journal of Clinical and Translational Science, September 2024

MN Cup Division Winner!

XanthosHealth is HONORED to be the WINNER of Minnesota Cup’s Impact Ventures Division. Congratulations to all, and MANY THANKS to all who have supported and encouraged us on this journey! We are building a Community Approach to Facing Cancer one step at a time.

XanthosHealth is HONORED to be the WINNER of Minnesota Cup’s Impact Ventures Division. Congratulations to all, and MANY THANKS to all who have supported and encouraged us on this journey! We are building a Community Approach to Facing Cancer one step at a time.

Thank you CancerX

Thank you CancerX for letting XanthosHealth be a member of your inaugural class!! This is another major milestone for XanthosHealth. We graduated from the CancerX Moonshot accelerator after four months of intensive learning developing growth strategy to scale our innovative digital social care referral platform! We are grateful to CancerX Moonshot and its partners, MassChallenge, …

Thank you CancerX for letting XanthosHealth be a member of your inaugural class!! This is another major milestone for XanthosHealth. We graduated from the CancerX Moonshot accelerator after four months of intensive learning developing growth strategy to scale our innovative digital social care referral platform! We are grateful to CancerX Moonshot and its partners, MassChallenge, Moffitt […]

XanthosHealth Awarded STTR From National Institutes Of Health

XanthosHealth is excited to receive an almost $1.9 million STTR Phase 2 grant from the National Cancer Institute (NCI). This two-year project, ConnectedNest: a digital platform connecting individuals with cancer to social care”, is in partnership with University of Minnesota and will enhance ConnectedNest’s technical features, and conduct a randomized clinical trial recruiting patients from …

XanthosHealth is excited to receive an almost $1.9 million STTR Phase 2 grant from the National Cancer Institute (NCI). This two-year project, ConnectedNest: a digital platform connecting individuals with cancer to social care”, is in partnership with University of Minnesota and will enhance ConnectedNest’s technical features, and conduct a randomized clinical trial recruiting patients from […]